Daniel Knutson | CR&D Lead Principal Scientist

Education

• University of Wisconsin-Milwaukee, 2020, PhD, Medicinal and Organic Chemistry

• Rockford University, 1997, BS, Chemistry

• Rock Valley College, 1995, AS, Chemistry

Publications

• Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models December 2020

  ACS Pharmacology and Translational Science

• Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation October 2020

  bioRxiv

• Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation October 2020

  Cerebral Cortex

• α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia October 2020

  Neurotherapeutics

• Improved Scale-up Synthesis and Purification of Clinical Asthma Candidate MIDD0301 July 2020

  Organic Process Research and Development

• The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects July 2020

  ACS Chemical Neuroscience

• The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects, and block chemotherapy-induced hyperalgesia, in mice without tolerance development July 2020

  Pharmacology Biochemistry and Behaviour

• Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance June 2020

  European Journal of Pharmaceutical Sciences

• The effect of pH on the structure and bio-availability of asthma drug candidate MIDD0301. February 2020

  Modular Pharmaceutics

• Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles January 2019

  Molecular Neuropychiatry

• Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha6GABAA receptors January 2019

  European Journal of Pain

• Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons January 2019

  Frontiers in Pharmacology

• mprovements in the pharmacological profile of diazepam by KRM-II-81, an imidizodiazepine positive allosteric modulator of a2/3-containing GABAA receptors: Preclinical data predict enhanced efficacy for epilepsy, chronic pain, anxiety, and depression

  Pharmaceutical Sciences and Biomedical Analysis Journal

• Rapid-Acting Antidepressants July 2018

  Current Pharmaceutical Design

• The α6 subunit-containing GABA A receptor: A novel drug target for inhibition of trigeminal activation July 2018

  Neuropharmacology

• Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders March 2018

  British Journal of Pharmacology

• Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability February 2018

  Journal of Medicinal Chemistry

Sterling Resources

• Deuteration in API development: Synthetic, analytical and engineering considerations April 2026

• Scaling ring-closing metathesis in API development: Challenges and success factors April 2026