Hazardous Chemistry

Delivering hazardous chemistry rooted in experience

With more than 50 years’ expertise in hazardous chemistry, we offer the specialised knowledge, state-of-the-art equipment, and proven methodology needed to safely handle hazardous chemical processes without compromising quality, cost effectiveness, and speed to market.

Hazardous chemistry at Sterling

Safely handling hazardous chemistry at scale is highly complex, requiring dedicated equipment and purpose-built facilities. As a result, hazardous chemistry outsourcing has become increasingly prevalent in API development and manufacturing. At Sterling, we combine our over 50 year track record in hazardous chemistry with expert teams, world-class equipment, and a proven hazard evaluation methodology that together enable us to safely handle even the most hazardous chemical processes. We also have a proven track record of designing and installing bespoke plant equipment for hazardous reactions.

Harnessing a multi-disciplinary, integrated approach to hazardous chemistry, we develop a tailored strategy for each customer’s project that maximises safety while maintaining efficiency and controlling costs. Close collaboration between our hazard evaluation, chemistry, and engineering teams enables us to successfully scale up hazardous processes while adhering to the highest standards of safety and compliance. ... Read more

We have the in-house expertise to offer a wide range of hazardous chemical reactions and substances.

Our hazardous chemistry capabilities include:

  • Diazomethane chemistry
  • Cyanide handling
  • Grignards and alkali metal handlings (including but not limited to butyl lithium/LiAlH4)
  • Phosgenation chemistry
  • Carbonylation chemistry
  • Hydrogenation reactions including 10 bar pressure capabilities and precious metal handling (Pt/Pd/Raney Ni)
  • Hydroxylamine reactions
  • Bulk bromine, chlorination, and fluorination chemistry
  • Nitration chemistry
  • Carbon monoxide, ethylene oxide, and propylene oxide handling and reactions
  • Potent and highly potent handling
  • Controlled substances handling (schedule 1, 2 and 3) Read less

Key Benefits

By partnering with Sterling for hazardous chemistry outsourcing, our customers realise several compelling advantages. These include:


Our hazardous chemistry services are rooted in more than 50 years of experience, enabling us to support a diverse range of project requirements.


With close collaboration between our hazard evaluation, chemistry, and engineering teams, we develop a tailored approach for each programme to ensure safety at every stage.


Our state-of-the-art process safety laboratories and specialised equipment enable us to safely scale up a variety of hazardous processes.

Prioritising safety throughout the product lifecycle

Though a process may not carry a high level of risk at lab scale, large-scale manufacturing brings a multitude of new process considerations. By providing full-lifecycle support to our customers, we identify areas that may pose safety concerns early on to proactively mitigate risk as we scale up our customers’ projects. Our vast experience working with hazardous chemistry at the commercial scale enables us to overcome complex challenges and deliver solutions that are safe, efficient, and cost-effective.

A robust approach to hazard evaluation

Hazard evaluation is a critical aspect of our new product introduction (NPI) process at Sterling. By pairing comprehensive chemical hazard evaluation with process design, our team minimises risk at each stage of your project while ensuring ongoing efficiency and scalability. With a world-class hazard evaluation laboratory, a wide range of specialised equipment, and a highly skilled team with more than five decades of hazard evaluation experience, we empower our customers to overcome complex hazardous chemistry challenges to ensure their projects’ success.

Our NPI procedures allow us to identify and assess hazards to ensure that not only process hazards are recognised, but the full handling and containment aspects or materials, intermediates and products are also fully assessed.

As multi-step processes are often required to produce the innovative and complex products in the pipeline today, it is almost a given that these projects will require hazardous chemistry at some stage. At Sterling, our team pairs full-lifecycle support with strong hazardous chemistry expertise to make sure all of our customers’ projects are safe, scalable, efficient, and cost-effective.

Scott Duffy | Hazard Evaluation Chemist

Related Services and Technologies

Related Content

Making Sense of

Making sense of hazard evaluation


High Potency APIs are on the rise


Positioning your HPAPI programme for success webinar

Related Pages


About Us