Facility overview video: Newcastle Biosphere, UK

At Sterling, our integrated global facilities enable us to support a range of specialised project requirements for our customers.

Welcome to our Newcastle Biosphere, UK facility which specialises in chemistry services and process development for small molecules.

Let’s take a closer look at five things you should know about our Newcastle Biosphere facility.

The Newcastle Biosphere facility supports a breath of drug discovery services with experience in high throughput screening to identify hits, lead optimisation, and preparation of literature compounds to understand structure activity relationships. The Newcastle team helps customers identify an optimal target compound to achieve their desired therapeutic effect.

The Newcastle Biosphere facility specialises in the synthesis of complex organic molecules. Our teams expertise in complex chemistry organometallic catalysis, pro drugs, and isotope labelling enable us to support customers in efficiently synthesising small molecules with a given target structure.

To aid in optimising research and development, the site can support a range of specialised analytical services. The Newcastle Biosphere facility has strong capabilities in LCMS, HPLC, and NMR. This, paired with expertise in stable isotope preparation and metabolite synthesis, allows for a comprehensive understanding of drug metabolism and pharmacokinetic properties.

Once an appropriate compound is identified and developed, the Newcastle Biosphere facility can provide robust early stage scale-up support. Our team supports customers in developing non-GMP supply for toxicology studies to help contain costs while providing reliable safety data. This leads to process development and optimisation to support commercial scale-up at Sterling’s global facilities.

Finally, the Newcastle Biosphere facility has extensive experience in supporting patent development. Our expertise in process improvement has led to numerous new patents for our customers and we support their filings by delivering focus compound libraries in an efficient and cost-effective manner.

Sterling’s Newcastle Biosphere facility can help you set your small molecule project up for success from day one.