Reduced subunit analysis of a therapeutic monoclonal antibody
28th Mar 2022
Biologics represent a growing class of pharmaceuticals being developed to target a variety of disease and illness vectors. As well as established monoclonal antibodies, new modalities are emerging such as bispecific antibodies with differing heavy or light chains. Some of these features such as stoichiometry and glycan profiling can be defined as critical quality attributes (CQAs). Use of subunit analysis through reduction or specifc cleavage enzymes like IdeS can be used to simplify the observed spectra to better qualify these attributes.
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