The growing demand for hazardous chemistry brings new risks that require both chemistry and engineering expertise
As new chemical entities (NCEs) with greater molecular complexity enter drug development pipelines, the demand for hazardous chemistry techniques is growing.
Hazardous chemistry can provide access to synthetic routes for active pharmaceutical ingredients (APIs) which overall involve fewer process stages. Whilst these alternative routes of synthesis are not always considered during the earlier phases of development due to the risks involved, they allow API manufacturers, with the right experience, to develop more direct and cost-effective processes that will produce higher yields.
In this article for Pharmaceutical Manufacturing, Paul Moscrop, Process Engineering Manager at Sterling Pharma Solutions analyses the requirement for hazard evaluation and the role of the process engineer when it comes to hazardous chemistry.