Solid State Scientist

Location: Dudley, Northumberland, UKDepartment: Research and DevelopmentReference: VN042
Summary of Solid State Scientist role

We are seeking a chemist or scientist in material science of organic substances to join our Quality team based at Dudley, Northumberland, UK. The successful candidate will apply solid state techniques in order to understand materials behaviour for selection and progression as developable materials and perform comprehensive and definitive physical form screening using a wide range of methodologies including equilibration transformations and solution crystallisations for the production of small quantities of intermediates and Active Pharmaceutical Ingredients (APIs) in a safe and current good manufacturing practise (cGMP) compliant manner. Successful candidates will also be expected to perform analysis and related activities in accordance with the requirements of cGMP.

Solid state chemistry development at Sterling's facilities, enables us to deliver improved material efficiency. Our team of experts have a range of tools and techniques to support a detailed crystallisation development programme, which aims to deliver an API with the desired characteristics, suitable for drug product manufacture or determine the appropriate solution from our bulk particle manipulation facilities.

As Sterling is a contract development and manufacturing organisation (CDMO), project assignments will be varied in nature and will always include hands on laboratory work.  Strong scientific reasoning, problem solving skills and flexibility in order to manage complex challenges will be required.

Our projects require a multidisciplinary team and the appointed individual will be expected to collaborate with a knowledgeable, diverse and international project team in an expanding company.

Responsibilities
 
  • Perform salt and polymorphism screening investigations and crystallisation development and report findings
  • Characterise samples/materials by solid state techniques (X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), dynamic vapour sorption (DVS), microscopy, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), particle size distribution (PSD), ion chromatography (IC), gas chromatography (GC) and high performance liquid chromatography (HPLC)) and report findings
  • Perform cGMP review and analytical approval of materials and calibration and maintenance of analytical equipment to meet cGMP and operational requirements
  • Develop, evaluate and prepare analytical methods, monographs, protocols and standard operating procedures (SOPs)
  • Ensure and support cGMP and GLP compliance
  • Support scientists in solid state matters and carry out training of less experienced scientists
  • Liaise with manufacturing, technical and operational quality personnel on relevant aspects of compliance and analytical atypicality
  • Perform technical transfers between internal and external customers
  • Support method validation programs and auditing of laboratory areas.
  • Support cGMP stability programs
  • Characterise reference materials for use in cGMP analysis.
  • Embody our values, which are: be reliable, be caring, be transparent and be willing.

Key Skills and Competencies
 
  • Minimum of a bachelor’s degree in chemistry or material science of organic substances or related discipline.
  • Several years practical experience in salt and polymorphism screening investigations and crystallisation development and selection of API candidates is advantageous 
  • Several years practical experience of solid-state characterisation is advantageous 
  • Ideally, experience working within a cGMP environment
  • Good verbal communications skills
  • Attention to detail and good organisational skills
  • Ability to work well as part of a team and independently
  • Strong practical laboratory skills and ability to work flexibly and adapt to changing priorities.

We also require candidates to be competent with IT systems, and in particular Microsoft Office including Outlook, PowerPoint, Word and Excel.

You will receive

A competitive salary, pension scheme, Perkbox, healthcare, 25 days annual leave, death in service coverage, on-site health and wellbeing support and medical consultation and physiotherapy, 24/7 employee assistance programme. Training and opportunities for further career development.

Why consider Sterling?

Sterling Pharma Solutions is a global contract development and manufacturing organisation (CDMO) with more than 50 years’ experience in developing and manufacturing Active Pharmaceutical Ingredients (APIs).  This is complimented by Antibody Drug Conjugate (ADC) research and development bioconjugation services.

We are a fast growing, dynamic business with facilities in the UK and the US, where we employ more than 800 talented and passionate people who support our customers in bringing new medicines to market, improving and saving the lives of patients.

Our culture and our way of working is what really sets us apart as a business; we aim to deliver an exceptional experience to our customers and our employees.  You can expect to be part of a supportive team, all working towards a shared goal: to deliver first-class science and service to our customers every day. 


Sterling Pharma Solutions is an equal opportunity employer.
Be caring. Be transparent. Be willing. Be reliable.
Deadline for applications: 22 Oct 2021
Service. Passion. Science.