Measurement of ADC stability in plasma via released payload quantitation
28th Mar 2022
Antibody drug conjugates (ADCs) represent highly heterogenous molecules with the inherent variations of an antibody combined with the addition of cytotoxic payloads and linkers. When measuring these samples for stability, either in plasma or during storage, there needs to be robust analytical methods to monitor specific critical quality attributes (CQAs). If the linker is designed to be cleaved this can be used to measure the amount of payload present via a quantitive MRMHR type method.
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