Measurement of ADC stability in plasma via released payload quantitation

28th Mar 2022

Antibody drug conjugates (ADCs) represent highly heterogenous molecules with the inherent variations of an antibody combined with the addition of cytotoxic payloads and linkers. When measuring these samples for stability, either in plasma or during storage, there needs to be robust analytical methods to monitor specific critical quality attributes (CQAs). If the linker is designed to be cleaved this can be used to measure the amount of payload present via a quantitive MRMHR type method.

Click below to read more.

Download resource

Related Content

Mass Spectrometry


ADC Analytical Services

Reduced Subunit Analysis of a Cysteine Linked Antibody Drug Conjugate


Native intact analysis of a cysteine linked antibody drug conjugate


Intact mass analysis of a therapeutic lysine linked antibody drug conjugate


Intact Mass Analysis of a Therapeutic Monoclonal Antibody Biosimilar


Peptide digestion analysis of a monoclonal therapeutic antibody

Measurement of ADC Stability in Serum via Subunit DAR Analysis