From our UK manufacturing facility, we can take your projects from development through to clinical trial manufacture and commercial supply. With the technologies and capacity to manufacture at a wide range of scales, we provide an agile and fully compliant API manufacturing service.

We have made significant investments into our dedicated development centre and pilot plant to ensure we can support innovative API development requirements and the scale-up of your projects from small scale to commercial production.

Development

Our dedicated development centre helps you to meet your innovator API development requirements.

Our team of more than 70 skilled scientists provide comprehensive capabilities including:

  • cGMP kilo lab facilities at 10, 20, 25 and 50L for clinical and commercial API batches up to ~5kg
  • High potency capability at 10 and 20L
  • 10 and 20L small scale cGMP hydrogenation equipment
  • Full range of supporting analytical services including LCMS, XRPD, ICPMS and NMR
  • Validation support services (DoE, QbD)
  • 32 fume hoods
  • Multi block reactors, process intensification
  • World class hazard evaluation laboratory
  • Expertise in technology transfer, process development and industrialisation
  • Solid State Chemistry team to support solid form development

Pilot plant

Our pilot plant ensures we can support the scale-up of your API projects.

Our pilot plant capabilities include:

  • Six independent, highly flexible reactor bays
  • 200– 1,300 litre scale
  • Clinical and commercial API and intermediate capability
  • Range of Aurora filters, pressure filters, centrifuges and tray driers
  • Biotage chromatographic purification unit
  • Controlled substance manufacture
  • High containment for charging and offloading potent APIs and problematic materials (e.g. HF/pyridine)
  • Temperature capability from -20 to +180°C
  • High vacuum WFE / SPE unit and high temperature fractionating unit

Manufacturing

Our modern, agile small molecule API manufacturing facilities offer:

  • Broad range of intermediate and API trains
  • 1,200 – 13,500 litre scale
  • Range of pressure filters, centrifuges and blender driers
  • USP purified water system
  • Cryogenic capability (-90°C)
  • High temperature capability (+200°C)
  • High vacuum WFE / SPE unit; fractionating unit – 30 theoretical plates
  • Range of milling facilities in cleanroom environment
  • Extensive range of capabilities including fluorination, hydroxylamine, organometallic, friedel craft and carbonylation
  • Bulk Br2 Cl2 H2, ethylene oxide, propylene oxide

UK Headquarters

Sterling Place, Dudley
Cramlington
Northumberland
NE23 7QG
United Kingdom

UK telephone: +44 (0) 191 250 0471