Sterling have scaled up the Jacobsen Mn Salen epoxidation technology to provide high chiral purity on a MTonne scale. A vast array of cyclic and terminal alkenes (e.g. indenes, eneynes and chromenes) have been converted into chiral epoxides with excellent enantiomeric purity and yields using Mn Salen catalysis and low cost oxidants such as sodium hypochlorite. This powerful tool has been enhanced through ongoing optimisation of the manufacturing process conditions, and through the application of new catalyst variants. Sterling have additional expertise in the downstream functionalisation of the chiral epoxides to generate a range of pharmaceutical and speciality chemicals with high chiral purity.

Key Features:

  • Sterling operates Jacobsen’s epoxidation at > 1500L scale

  • A broad range of alkenes including cyclopentene, indene and acyclic yne-ene substrates, which have been subject to chiral epoxidation on a pilot scale