Our chiral reduction capabilities, including aminoindanol reduction, chiral hydrogenation and enzymatic reduction, give our clients cost effective access to high purity complex intermediates and APIs.

Aminoindanol reduction

Our experts have industrialised a proprietary aminoindanol chiral reduction technology and routinely operate this on >300kg scale.

Core capabilities:

  • Low catalyst loading
  • Typical e.e. > 95-99%
  • Isolated yield typically > 85%

Chiral hydrogenation

We can provide you with scale-up expertise involving a range of chiral hydrogenation catalysts and both small scale flow hydrogenation and large scale hydrogenation capacity.

Core capabilities:

  • Expertise in chiral hydrogenation catalysts at development scale
  • Production scale experience of chiral hydrogenation (using catalysts such as Ru BINAP)
  • Significant investment to enhance hydrogenation capacities at varying scales (from 10lt to 2.2m3)

Enzymatic reduction

Through collaboration with Northumbria University, Sterling can provide you with rapid enzyme screening coupled with development and scale-up expertise to provide biocatalytic solutions to your chemistry challenges.

Sterling has completed an Innovate UK sponsored project with a local biotech company. During this project several hundred new and novel keto reductases were synthesised in order to investigate the replacement of an expensive third party catalyst with a cost effective bio-catalytic process.

Contact usto find out more about our chiral reduction capabilities.