Fluorinations

Sterling have an extensive range of fluorination capabilities and are continually evaluating options to enhance this capability. We carry out fluorination reactions on scales ranging from grams to hundreds of kilos and can handle highly hazardous fluorination agents based on our onsite hazard evaluation expertise. Key chemistries range from basic transformations, such as Balz-Schiemann, Halex, nucleophilic and electrophilic fluorination, to more differentiating technologies like fluoroalkoxylation, fluorocarbene and radical trifluoromethylation.

Among the most distinctive technologies at Sterling are radical and carbene-based fluorine chemistry, with a particular focus on trifluoromethylation techniques. We have developed radical trifluoromethylation technology over the years and can control this hazardous chemistry to offer a range of trifluoromethyl alkyl derivatives at Mtonne scale.

Sterling can process the fluorinated aliphatic compounds onwards to a range of functionalised chiral and non-chiral derivatives, tapping into proprietary kinetic resolution technology to generate trifluoromethyl epoxide and alcohol derivatives. This technology fits well with our existing chiral chemistry expertise and enables us to offer both new chiral and a chiral fluorinated building blocks on a competitive basis